TPCN2

Two pore segment channel 2
Identifiers
Symbols	TPCN2 ; SHEP10; TPC2
External IDs	OMIM: 612163 MGI: 2385297 HomoloGene: 16375 IUPHAR: 393 GeneCards: TPCN2 Gene
Gene ontology Molecular function • voltage-gated calcium channel activity • protein binding • protein kinase binding • identical protein binding • NAADP-sensitive calcium-release channel activity Cellular component • lysosomal membrane • plasma membrane • endosome membrane • integral component of membrane Biological process • calcium ion transport • cellular calcium ion homeostasis • smooth muscle contraction • lysosome organization • calcium-mediated signaling • response to vitamin D • ion transmembrane transport • regulation of ion transmembrane transport • release of sequestered calcium ion into cytosol • transmembrane transport • calcium ion transmembrane transport • membrane depolarization during action potential Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	219931	233979
Ensembl	ENSG00000162341	ENSMUSG00000048677
UniProt	Q8NHX9	Q8BWC0
RefSeq (mRNA)	NM_139075	NM_146206
RefSeq (protein)	NP_620714	NP_666318
Location (UCSC)	Chr 11: 69.05 – 69.09 Mb	Chr 7: 145.25 – 145.28 Mb
PubMed search	[1]	[2]

Two pore segment channel 2 (TPC2) is a human protein encoded by the TPCN2 is a protein which in humans is encoded by the TPCN2 gene. TPC2 is an ion channel, however, in contrast to other calcium and sodium channels which have four homologous domains, each containing 6 transmembrane segments (S1 to S6), TPCN1 only contains two domain (each containing segments S1 to S6).

See also

• Two-pore channel

External links

• TPCN2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)