TRPC1

Transient receptor potential cation channel, subfamily C, member 1
Identifiers
Symbols	TRPC1 ; HTRP-1; TRP1
External IDs	OMIM: 602343 MGI: 109528 HomoloGene: 2478 IUPHAR: 486 GeneCards: TRPC1 Gene
Gene ontology Molecular function • cation channel activity • calcium channel activity • protein binding • store-operated calcium channel activity • ion channel binding • inositol 1,4,5 trisphosphate binding Cellular component • cytosol • plasma membrane • integral component of plasma membrane • basolateral plasma membrane • sarcomere • costamere • receptor complex • membrane raft Biological process • calcium ion transport • manganese ion transport • axon guidance • ion transmembrane transport • melanin biosynthetic process • saliva secretion • positive regulation of release of sequestered calcium ion into cytosol • cytosolic calcium ion homeostasis • response to calcium ion • transmembrane transport • calcium ion transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE TRPC1 205803 s at tn.png
File:PBB GE TRPC1 205802 at tn.png
File:PBB GE TRPC1 211602 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7220	22063
Ensembl	ENSG00000144935	ENSMUSG00000032839
UniProt	P48995	Q61056
RefSeq (mRNA)	NM_001251845	NM_011643
RefSeq (protein)	NP_001238774	NP_035773
Location (UCSC)	Chr 3: 142.72 – 142.81 Mb	Chr 9: 95.71 – 95.75 Mb
PubMed search	[1]	[2]

Transient receptor potential channel 1 (TRPC1) is a protein that in humans is encoded by the TRPC1 gene.

Function

TRPC1 is an ion channel located on the plasma membrane of numerous human and animal cell types. It is a nonspecific cation channel, which means that both sodium and calcium ions can pass through it. TRPC1 is thought to mediate calcium entry in response to depletion of endoplasmic calcium stores or activation of receptors coupled to the phospholipase C system. In HEK293 cells the unitary current-voltage relationship of endogenous TRPC1 channels is almost linear, with a slope conductance of about 17 pS. The extrapolated reversal potential of TRPC1 channels is +30 mV. The TRPC1 protein is widely expressed throughout the mammalian brain and has a similar corticolimbic expression pattern as TRPC4 and TRPC5. The highest density of TRPC1 protein is found in the lateral septum, an area with dense TRPC4 expression, and hippocampus and prefrontal cortex, areas with dense TRPC5 expression.

History

TRPC1 was the first mammalian Transient Receptor Potential channel to be identified. In 1995 it was cloned when the research groups headed by Craig Montell and Lutz Birnbaumer were searching for proteins similar to the TRP channel in Drosophila. Together with TRPC3 they became the founding members of the TRPC ion channel family.

Interactions

TRPC1 has been shown to interact with:

• HOMER3,
• Polycystic kidney disease 2,
• RHOA
• TRPC3,
• TRPC4, and
• TRPC5.

See also

• TRPC

External links

• TRPC1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.