TRPV2

Transient receptor potential cation channel, subfamily V, member 2
250px PDB rendering of the ankyrin repeat substructure of TRPV2, based on 2f37.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2F37
Identifiers
Symbols	TRPV2 ; VRL; VRL-1; VRL1
External IDs	OMIM: 606676 MGI: 1341836 HomoloGene: 7993 IUPHAR: 508 ChEMBL: 5051 GeneCards: TRPV2 Gene
Gene ontology Molecular function • ion channel activity • cation channel activity • calcium channel activity • ion transmembrane transporter activity Cellular component • plasma membrane • integral component of plasma membrane • cell surface • growth cone membrane • melanosome • axonal growth cone • cell body Biological process • transport • sensory perception • response to temperature stimulus • response to heat • ion transmembrane transport • positive regulation of axon extension • transmembrane transport • calcium ion transmembrane transport • positive regulation of calcium ion import Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE TRPV2 219282 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51393	22368
Ensembl	ENSG00000187688	ENSMUSG00000018507
UniProt	Q9Y5S1	Q9WTR1
RefSeq (mRNA)	NM_016113	NM_011706
RefSeq (protein)	NP_057197	NP_035836
Location (UCSC)	Chr 17: 16.42 – 16.44 Mb	Chr 11: 62.57 – 62.6 Mb
PubMed search	[1]	[2]

Transient receptor potential cation channel subfamily V member 2 is a protein that in humans is encoded by the TRPV2 gene.

Function

This gene encodes an ion channel that is activated by high temperatures above 52 °C. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat.

History

TRPV2 was independently discovered by two research groups and described in 1999. It was identified in the lab of David Julius as a close homolog of TRPV1, the first identified thermosensitive ion channel. The group of Itaru Kojima from Gunma University was looking for a protein which is responsible for the entry of calcium into cells in response to insulin-like growth factor-1 (IGF-1). Upon stimulation of cells with IGF-1 TRPV2 translocates towards and integrates into the cell membrane and increases intracellular calcium concentrations.

Activators and inhibitors

TRPV2 is activated by high temperatures above 52 °C. Alternatively it can be activated at lower temperatures by chemicals, such as the research tool 2-APB, the plant cannabinoid cannabidiol, and probenecid. It is blocked by ruthenium red and lanthanum.

See also

• TRPV
• Ruthenium red

External links

• TRPV2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.