TRPC4

Transient receptor potential cation channel, subfamily C, member 4
Identifiers
Symbols	TRPC4 ; HTRP-4; HTRP4; TRP4
External IDs	OMIM: 603651 MGI: 109525 HomoloGene: 22955 IUPHAR: 489 GeneCards: TRPC4 Gene
Gene ontology Molecular function • protein binding • beta-catenin binding • store-operated calcium channel activity • cadherin binding • inositol 1,4,5 trisphosphate binding Cellular component • cytosol • plasma membrane • integral component of plasma membrane • caveola • cell-cell junction • cell surface • basolateral plasma membrane • cortical cytoskeleton • calcium channel complex Biological process • calcium ion transport • manganese ion transport • axon guidance • gamma-aminobutyric acid secretion • ion transmembrane transport • oligodendrocyte differentiation • cytosolic calcium ion homeostasis • regulation of calcium ion transport • transmembrane transport • calcium ion import • calcium ion transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7223	22066
Ensembl	ENSG00000133107	ENSMUSG00000027748
UniProt	Q9UBN4	Q9QUQ5
RefSeq (mRNA)	NM_001135955	NM_001253682
RefSeq (protein)	NP_001129427	NP_001240611
Location (UCSC)	Chr 13: 37.64 – 37.87 Mb	Chr 3: 54.16 – 54.32 Mb
PubMed search	[1]	[2]

The short transient receptor potential channel 4 (TrpC4), also known as Trp-related protein 4, is a protein that in humans is encoded by the TRPC4 gene.

Function

TrpC4 is a member of the transient receptor potential cation channels. This protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation.

Tissue distribution

The nonselective cation channel TrpC4 has been shown to be present in high abundance in the cortico-limbic regions of the brain. In addition, TRPC4 mRNA is present in midbrain dopaminergic neurons in the ventral tegmental area and the substantia nigra.

Roles

Deletion of the trpc4 gene decreases levels of sociability in a social exploration task. These results suggest that TRPC4 may play a role in regulating social anxiety in a number of different disorders. However deletion of the trpc4 gene had no impact on basic or complex strategic learning. Given that the trpc4 gene is expressed in a select population of midbrain dopamine neurons it has been proposed that is may have an important role in dopamine related processes including addiction and attention.

Clinical significance

Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity.

Interactions

TRPC4 has been shown to interact with ITPR1, TRPC1, and TRPC5.

See also

• TRPC

External links

• TRPC4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.