Arginine vasopressin receptor 2

Arginine vasopressin receptor 2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4JQI
Identifiers
Symbols	AVPR2 ; ADHR; DI1; DIR; DIR3; NDI; V2R
External IDs	OMIM: 300538 MGI: 88123 HomoloGene: 20064 IUPHAR: 368 ChEMBL: 1790 GeneCards: AVPR2 Gene
Gene ontology Molecular function • vasopressin receptor activity • protein binding • peptide binding Cellular component • endosome • endoplasmic reticulum • Golgi apparatus • plasma membrane • integral component of plasma membrane • integral component of membrane Biological process • regulation of systemic arterial blood pressure by vasopressin • positive regulation of systemic arterial blood pressure • renal water homeostasis • water transport • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • activation of adenylate cyclase activity • I-kappaB kinase/NF-kappaB signaling • excretion • hemostasis • positive regulation of cell proliferation • positive regulation of gene expression • telencephalon development • positive regulation of protein ubiquitination • interferon-gamma production • cellular response to hormone stimulus • response to cytokine • negative regulation of urine volume • negative regulation of renal sodium excretion • positive regulation of vasoconstriction • transmembrane transport • response to peptide Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	554	12000
Ensembl	ENSG00000126895	ENSMUSG00000031390
UniProt	P30518	O88721
RefSeq (mRNA)	NM_000054	NM_001276298
RefSeq (protein)	NP_000045	NP_001263227
Location (UCSC)	Chr X: 153.9 – 153.91 Mb	Chr X: 73.89 – 73.9 Mb
PubMed search	[1]	[2]

Arginine vasopressin receptor 2 (officially abbreviated AVPR2) is a protein that acts as receptor for arginine vasopressin. AVPR2 belongs to the subfamily of G-protein-coupled receptors. Its activity is mediated by the G_s type of G proteins, which stimulate adenylate cyclase.

AVPR2 is expressed in the kidney tubule, predominantly in the membrane of cells of the distal convoluted tubule and collecting ducts, in fetal lung tissue and lung cancer, the last two being associated with alternative splicing. AVPR2 is also expressed outside the kidney, and, when stimulated, a variety of clotting factors are released into the bloodstream.

In the kidney, AVPR2's primary property is to respond to arginine vasopressin by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of AVPR2 is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results.

Antagonists

Further information: Vasopressin receptor antagonist

Vasopressin receptor antagonists that are selective for the V2 receptor include:

• Tolvaptan (FDA-approved)
• Lixivaptan
• Mozavaptan
• Satavaptan

Their main uses are in hyponatremia, such as that caused by syndrome of inappropriate antidiuretic hormone (SIADH) and heart failure, however these agents should be avoided in patients with cirrhosis.

Demeclocycline and lithium carbonate act as indirect antagonists of renal vasopressin V₂ receptors by inhibiting activation of the second messenger cascade of the receptors.

Interactions

Arginine vasopressin receptor 2 has been shown to interact with C1QTNF1.

External links

• GeneReviews/NCBI/NIH/UW entry on Nephrogenic Diabetes Insipidus