SB-258585

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SB-258585
SB258585.png
Systematic (IUPAC) name
4-Iodo-N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]benzenesulfonamide
Identifiers
CAS Number 209480-63-7 YesY
PubChem CID: 3248571
IUPHAR/BPS 3232
ChemSpider 2498938 N
ChEMBL CHEMBL60264 N
Chemical data
Formula C18H22IN3O3S
Molecular mass 487.354 g/mol
  • C3CN(C)CCN3c1cc(ccc1OC)NS(=O)(=O)c2ccc(I)cc2
  • InChI=1S/C18H22IN3O3S/c1-21-9-11-22(12-10-21)17-13-15(5-8-18(17)25-2)20-26(23,24)16-6-3-14(19)4-7-16/h3-8,13,20H,9-12H2,1-2H3 N
  • Key:BDHMSYNBSBZCAF-UHFFFAOYSA-N N
 NYesY (what is this?)  (verify)

SB-258585 is a drug which is used in scientific research. It acts as a potent, selective and orally active 5-HT6 receptor antagonist, with a Ki of 8.9nM.[1] It is used in its 125I radiolabelled form to map the distribution of 5-HT6 receptors in the brain.[2][3]

SB-258585 and other 5-HT6 antagonists show nootropic effects in animal studies,[4][5] as well as antidepressant and anxiolytic effects,[6] and have been proposed as potential novel treatments for cognitive disorders such as schizophrenia and Alzheimer's disease.

References

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