Bradanicline

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Bradanicline
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Systematic (IUPAC) name
N-[(2S,3R)-2-(Pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]-1-benzofuran-2- carboxamide
Identifiers
CAS Number 639489-84-2
PubChem CID: 16727410
UNII UM3821998K YesY
ChEMBL CHEMBL1258006
Synonyms TC-5619
Chemical data
Formula C22H23N3O2
Molecular mass 361.437 g/mol
  • C1CN2CCC1[C@@H]([C@@H]2CC3=CN=CC=C3)NC(=O)C4=CC5=CC=CC=C5O4
  (verify)

Bradanicline (INN) (code name TC-5619) is a drug which was being developed by Targacept that acts as a partial agonist at the α7 subtype of the neural nicotinic acetylcholine receptors. It showed cognitive enhancing effects in animal studies, and was being developed through a collaboration between Targacept and AstraZeneca as a potential treatment for schizophrenia and attention deficit disorder. [1] Phase I clinical trials were completed successfully, and it was in phase II trials.[2]

In May 2011, AstraZeneca declined to exercise its right to license the compound.[3] In September 2012, Targacept ended its development of badanicline for the purpose of treating ADHD in adults.[4] It was being studied for cognitive and memory enhancement.[5]

Bradanicline was discontinued for Alzheimer's disease and cognitive impairment in schizophrenia in late 2013.[6] It was also discontinued for ADHD, and no longer seems to be being developed.[6]

References

  1. ↑ TC-5619 Cognitive Dysfunction in Schizophrenia
  2. ↑ Rethinking Schizophrenia
  3. ↑ Targacept retains full development rights for TC-5619
  4. ↑ Targacept ends development of ADHD drug
  5. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  6. ↑ 6.0 6.1 http://adisinsight.springer.com/drugs/800026693



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