E2F1

Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene.

Function

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.

Transcription

E2F1 promoter[PAX8] => E2F1 [PMID 21602887]

Interactions

E2F1 has been shown to interact with:

• ARID3A,
• CUL1,
• Cyclin A1,
• Cyclin A2,
• GTF2H1,
• MDM4,
• NCOA6,
• NDN,
• NPDC1,
• PURA,
• PHB,
• RB1,
• RBL1,
• SKP2,
• SP1,
• SP2,
• SP3,
• SP4,
• TFDP1
• TOPBP1,
• TP53BP1, and
• UBC.

See also

• E2F
• Retinoblastoma protein

External links

• E2F1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook E2F1

This article incorporates text from the United States National Library of Medicine, which is in the public domain.