EGR2
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Early growth response protein 2 is a protein that in humans is encoded by the EGR2 gene.
Function
The early growth response protein 2 is a transcription factor with three tandem C2H2-type zinc fingers. Mutations in this gene are associated with the autosomal dominant Charcot-Marie-Tooth disease, type 1D,[1] Dejerine–Sottas disease,[2] and Congenital Hypomyelinating Neuropathy.[3] Two studies have linked EGR2 expression to proliferation of osteoprogenitors [4] and cell lines derived from Ewing sarcoma, which is a highly aggressive bone-associated cancer. [5]
References
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Further reading
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External links
- GeneReviews/NCBI/NIH/UW entry on Charcot-Marie-Tooth Neuropathy Type 1
- GeneReviews/NCBI/NIH/UW entry on Charcot-Marie-Tooth Neuropathy Type 4
- EGR2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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