LMX1A
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). LIM homeobox transcription factor 1, alpha, also known as LMX1A, is a protein which in humans is encoded by the LMX1A gene.[1][2]
Function
Insulin is produced exclusively by the beta cells in the islets of Langerhans in the pancreas. The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear genes that bind to specific sequences within the promoter of the insulin gene INS and interact with RNA polymerase to activate or repress transcription. LMX1 is a LIM homeobox transcription factor that binds an A/T-rich sequence in the insulin promoter and stimulates transcription of insulin.[3]
Interactions
LMX1A has been shown to interact with TCF3[4] and LHX3.[5]
References
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Further reading
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