Germ cell nuclear factor
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). The germ cell nuclear factor (GCNF), also known as RTR (retinoid receptor-related testis-associated receptor) or NR6A1 (nuclear receptor subfamily 6, group A, member 1), is a protein that in humans is encoded by the NR6A1 gene.[1][2] GCNF is a member of the nuclear receptor family of intracellular transcription factors .
In adults, GCNH is expressed mainly in the germ cells of gonads and is involved in the regulation of embryogenesis and germ cell differentiation.[3]
Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. The gene expresses three alternatively spliced transcript variants.[4]
References
Further reading
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External links
- NR6A1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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