USF1
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Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Upstream stimulatory factor 1 is a protein that in humans is encoded by the USF1 gene.[1][2]
Function
This gene encodes a member of the basic helix-loop-helix leucine zipper family and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Two transcript variants encoding distinct isoforms have been identified for this gene.[2]
A study of mice suggested reduced USF1 levels increases metabolism in brown fat.[3]
Interactions
USF1 (human gene) has been shown to interact with USF2,[4][5] FOSL1[6] and GTF2I.[7][8]
References
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Further reading
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External links
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